Can You Feel it in Your Gut? Researchers at NIH Study Probiotics, Poop, & People To Learn How Microbes & Genome Sequencing Can Keep Us Healthy

SITUATION:
There are millions of micro-organisms that help keep the body healthy.
Controlled by microbiomes that are essential component of immunity.
And functional entity that influences metabolism & modulates drug interactions.
These microbial cells hosted in our bodies like bacteria, viruses, & fungi.

SIGNIFICANCE:
The problem is researchers do not really know what all the microbes do.
Still Seeking to determine connections between microbes & ones health.
Could take decades to really understand role of microbes in your gut.
So need for a lot of research & study before popping probiotics.
Challenge for people & practitioners  is cultivating the right mix of microbes.
Restoring balance with fecal microbiota transplants (FMTs) is focus.

SOLUTIONS:
Presently, Fecal microbiota transplants (FMT can cure 90% of infections.
Objective, then, is to replace one that hurt with ones that seem to help.
Probiotics or good bacteria works best but is not yet the answer.
Human Microbiome Project looking at cancer, acne, Krones, & Alzheimers.
Studying donor’s encapsulated poop seems to be best way to introduce microbes.

STATS: How many microbes are in the human gut?
Human gut microbiota gathers more than 100 trillion microorganisms.
Weighs about 200g (equivalent to a medium-sized mango).
150/200 times more genes in individual’s microbiota than in all other cells.
Microbiologists estimate that 10 bacteria live in and on each of us.
Contains 10 times more cells than the whole human body.
Collective genomes (human microbiome) contain 100X more genes than human genome itself.

PEOPLE WORKING THE PROBLEM:
Lita Proctor, Former Director, National Institute of Health, Human Microbiome.

SOURCES:

“Could we fix our bodies by Fixing our Guts?” –Article by Kat Eschner, Popular Mechanics 2020 Winter Issue –https://www.popsci.com/tags/winter/

A new genomic blueprint of the human gut microbiota =https://www.nature.com/articles/s41586-019-0965-1

“The Microbes of the Intestine: An Introduction to Their Metabolic and Signaling Capabilities “ –https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411945/ease

“Microbes in us and their role……” – https://www.genome.gov/news/news-release/Microbes-in-us-and-their-role-in-human-health-and-disease

“What are probiotics? – https://my.clevelandclinic.org/health/articles/14598-probiotics

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